Preclinical CRO services in
Women’s Health
Gubra offers preclinical female health animal models for primary ovarian insufficiency (POI) and polyendocrine metabolic ovarian syndrome (PMOS; formally PCOS – polycystic ovary syndrome). We evaluate reproductive system function through estrous cycle monitoring, oocyte counts, and quantification and classification of follicles using both classical histological techniques and whole-ovary light-sheet fluorescence microscopy (LSFM). With AI evaluation of ovary composition, Gubra delivers actionable insights into ovarian health and tissue morphology. Collaborate with us to adapt these models and technologies to support your women’s health research.
Why Gubra?
- Expert scientific guidance in advanced women’s health research
- Validated translational POI and PMOS/PCOS models
- Comprehensive endpoints from estrous cycle monitoring to oocyte quantification
- Automated quantitative follicle classification by histology and LSFM
- Tailored study designs for specific female healthcare needs
Consult with Allison Butt
Senior Scientist, Scientific Sales
Advance your women’s health drug development with our innovative models and end points.
Discover Our Approaches for Advancing Women’s Health Research
Gubra provides advanced preclinical mouse models for POI and PMOS (previously PCOS). These models enable detailed evaluation of ovarian function through in-life estrous cycle monitoring and ex vivo endpoints. These models enable detailed evaluation of ovarian function through in-life estrous cycle monitoring and ex vivo endpoints. By combining traditional histology with whole-ovary light-sheet microscopy, we deliver both morphological insights and absolute 3D counts of oocytes and follicles. Our validated approach supports translational research and offers a robust platform for assessing therapeutic efficacy in women’s health care and female medicine.
Main Offerings
Translational POI and PMOS/PCOS models
Estrous cycle
monitoring
Whole ovary
morphological
imaging
Absolute oocyte
and follicle quantification
ACCELERATE YOUR DRUG PROFILING
Animal Female Health Models Available
Primary Ovarian Insufficiency (POI) mouse model
- Specialized animal model with oocyte population decreased via cyclophosphamide or cisplatin exposure
- For preclinical screening of compound efficacy in protecting oocyte reserves
- Standardized endpoints for consistent data delivery
Polyendocrine Metabolic Ovarian Syndrome (PMOS, formally PCOS) mouse model
- Female mice on a western diet with DHT implants to arrest follicle maturation (previously termed cysts)
- Monitoring of body mass, body composition, and insulin resistance
- Monitoring of estrous cycle using cytology
- Whole ovary measurements including quantification of follicles and corpus lutea
Explore cardiorenal effects of your preclinical candidate
Preclinical Female Model of Diabetic Kidney Disease
ReninAAV UNx db/db female mouse model
- State-of-the-art model of diabetes associated cardiorenal disease
- Progressive albuminuria and glomerulosclerosis
- Progressive hypertension, inflammation, and heart fibrosis
- Validated using standard of care (SoC) benchmark
- Ideal for profiling mono- and combination therapies
PROGRESS YOUR STUDY WITH GREATER CERTAINTY
Whole-Ovary Imaging for Absolute Oocyte or Follicle Counts
To accurately quantify ovarian follicle composition from samples sent to or generated within Gubra, we use industry-leading spatial biology techniques to determine the distribution and classification of follicles or count of oocytes across the entire ovary. This all-encompassing approach ensures precise visualization of ovary morphology, ovary composition, and quantifiable treatment outcomes via quantification of ovarian cell-type markers providing deep insights for your preclinical candidate.
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650