Technologies in
3D Imaging
Our light sheet microscopy and whole organ labelling are revolutionizing the understanding of disease progression and drug distribution. Gubra is industry-leading in whole organ imaging and AI-assisted quantification of histological markers. Our cutting-edge approach is shaping the future of 3D imaging in preclinical drug discovery.
Why Gubra?
- Immunolabeling of disease endpoints
- Whole organ ISH for receptor mapping
- Visualization of viral or non-viral gene delivery
- In vivo distribution of fluorescently labelled compounds
- AI-assisted quantification of endpoints
Consult with Senior Scientists
Allison Butt and Yasir Gallero-Salas
Discover how whole brain imaging can help you advance your drug development.
Get the full picture
with whole organ imaging
We can apply quantitative 3D light sheet microscopy to any organs in the mouse and rat. Our imaging platform is integrated into Gubra’s pipeline and works seamlessly in combination with our animal models and in-house developed algorithms to ensure absolute quantification of disease endpoints.
Main Offerings
Quantitative whole
organ imaging
Applicable to all organs
Segmentation of
complex 3D structures
Complete
pharmacological solutions
Multiplexed IHC &
ISH endpoints
In vivo distribution
Whole Organ Imaging Services
Kidney Diseases
- Precise quantification of glomeruli
- Determine changes in glomerular size
- Monitor vascular changes
Muscle
- Precise, quantitative characterization of whole-limb skeletal muscle morphology
- Individual muscle volume assessment
- Spatial mapping of capillary and nerve density, as well as collagen content
Cardiovascular Diseases
- Plaque burden in arteroschlerosis models
- Cardiac fibrosis
- Cardiac vascular network density
- Ventricular volume
Diabetes
-
Pancreatic islet/β-cell number and volume
-
Sympathetic innervation
-
Intra-islet Inflammation
Gene Therapy
- Visualize viral and non-viral gene delivery
- Visualize and quantify gene expression or knock-down
Vasculature
- Vascular density
- Branch points
- Vascular length
Customized Services
-
Ocular imaging
-
Adipose tissue
-
Spinal cord
- Others
Interpret complex organ effects
Explore Preclinical Endpoints in 3D
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650