Insight Resource Library Tap into Gubra’s vast production of publications, webinars, videos and posters to get the latest knowledge and insights within our focus areas: obesity, diabetes, MASH, CKD, IPF and IBD. 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progressive chronic kidney disease and kidney failure PosterEffect of lisinopril on glomerular and tubular injury in a surgical rat model of progressive chronic kidney disease and kidney failure PublicationProtection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R PosterWhole-brain 3D mapping and quantification of pathological α-Synuclein aggregate spreading and toxicity in a mouse model of early-stage Parkinson’s disease WebinarWhole organ staining and 3D light sheet imaging for pharmacological research PublicationWhole-brain activation signatures of weight-lowering drugs PublicationQuantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson’s disease PosterWhole-brain activation signatures of weight-lowering drugs WebinarUsing whole brain imaging for development of obesity drugs PublicationHepatoprotective effects of the long-acting FGF21 analogue PF-05231023 in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH PosterPreclinical efficacy and clinical translatability of long-acting FGF-21 analogue in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH PublicationNephroprotective effects of semaglutide as mono- and combination treatment with lisinopril in a mouse model of hypertension-accelerated diabetic kidney disease PublicationStructurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease WebinarWhole brain imaging using light sheet microscopy PosterQuantitative whole-brain 3D imaging of dopaminergic cell architecture in the mouse MPTP model of Parkinson’s disease PosterTranscriptomic profiling of renal cortical and glomerular changes in a uninephrectomized, hypertension-accelerated mouse model of advanced diabetic kidney disease PublicationPeptide-YY3-36/glucagon-like peptide-1 combination treatment of obese-diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries PublicationTherapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease PublicationA genetic map of the mouse dorsal vagal complex and its role in obesity PublicationEffect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography PublicationIdentification and metabolic profiling of a novel human gut-derived LEAP2 fragment PublicationWhole-brain 3D imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases PublicationThe dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity PublicationGlobal transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight 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