In vivo pharmacology

How we do it
Our in vivo expertise runs the gamut, from acute testing of compounds in mice and rats to chronic studies. We have experience with basically all commercially available rodent models used in obesity and diabetes testing. Our in vivo services include metabolic profiling, blood biochemistry and hormone analysis, as well as optional histopathology and histology/stereology.

In vivo pharmacology brochures:

Gubra obesity studies

Gubra preclinical diabetes



Metabolic phenotyping

Giving you a clearer understanding of a compound’s impact on metabolism

We have numerous tools to provide you with pivotal information about your compound and its effects on food intake, glucose and lipid metabolism, energy expenditure and cardiovascular regulation. We have state-of-the-art equipment in place for phenotyping your compounds and giving you the answers you need.

We offer:

  • Acute studies in mice and rats to record online food and water intake and locomotor activity.
  • Taste aversion and pica behavior
  • ICV and brain site-specific compound administration
  • Total body fat measurements in live animals using our EchoMRI scanner.
  • Tissue specific fat content using our MRI scanner.
  • Energy expenditure using indirect calorimetry
  • Oral/intravenous/intraperitoneal glucose tolerance tests (OGTT, IVGTT, IPGTT)
  • Continuous (24h) glucose monitoring in rats and hamsters
  • Measuring insulin sensitivity using the hyperinsulinaemic euglycaemic clamp
  • Advanced surgical models: SDA and Pancreatectomy

Check out our in vivo and metabolic phenotyping methodologies under Focus Areas: Obesity and Diabetes

Why experience matters

Animal testing ranges from the very simple to the extraordinarily complex. In order to offer you reliable results, it is critical that we have experience with every type of animal model.

Animal models have a tendency to drift over time and need to be constantly monitored and tested to ensure efficacy. We continually benchmark and monitor them, and our familiarity with their reactions and behaviors translates into accurate results for your research project.

We never perform studies that we do not believe answer pivotal questions for your project and always aim to deliver answers that can help you make substantiated decisions.

Animal Welfare

Gubra believes that laboratory animal welfare is an ethical responsibility that encompasses all aspects of animal well-being, including proper housing, clinical and behavioral management, nutrition, disease management and treatment, responsible care and use, humane handling and, when necessary, humane euthanasia.

We are dedicated to science, yet we live up to the highest standards of animal welfare. The Danish authorities have approved our in vivo facilities, and several of the world’s leading pharmaceutical companies have audited our facilities. A veterinarian monitors all of our animals and we conduct all animal-related activities in accordance with Danish Legislation, with records and welfare statements published annually in accordance to the Danish regulatory authorities.



The business value
of science Read

We know our results ultimately have to generate value for your company. That’s why we focus on the quality and completeness of the data we provide. We choose the methodology that will yield the most usable results for your company. Scientific research requires care, accuracy and precision. This is the delicate balance we walk. Pursuing methods with scientific merit to give you results that you can use, and that will ultimately generate value for your business.

Quality
assurance Read

At Gubra, we are committed to high quality deliverables. Through the strength of our quality systems and processes, from administration and study conduction to data management and reporting, we provide structured, professional and experienced services. All critical processes are governed by Standard Operating Procedures that along with quality control documentation are controlled by our Quality Assurance Group. Consistent training and evaluation processes throughout the organization ensure Gubras dynamic and evolving Quality Assurance System.

Why we
keep it simple Read

Just because it’s science, doesn’t mean the research has to be complicated. One of our mantras is the need to get clear, simple answers from research. It’s true, with limited time and resources and infinite pressure to produce results, it can be very tempting to get the most bang for your proverbial buck by trying to include as many endpoints in a study as possible. Yet, what often happens with this approach is that you get inconclusive results that require further investigation, taking more time and using more resources. By taking a straightforward approach to study design, we ensure our customers get clear answers they can use.